Imidazo[1,2-b]pyridazine
| Post Date: |
Dec 07,2018 |
| Expiry Date: |
Dec 07,2019 |
| Detailed Description: |
Cas No. :766-55-2
Abstract A large range of substituted imidazo[1,2-b]pyridazines have been synthesized, and a number of potent ligands at central benzodiazepine (Bz) receptors on rat brain membranes have been identified in initial binding screens using [3H]diazepam. For those tested more extensively, binding studies conducted in the presence and absence of gamma-aminobutyric acid suggest that they were full receptor agonists. Some preliminary evidence was found suggesting some species selectivity, i.e. several of the compounds were more active in in vivo tests in rats than in mice. The agonist activity of these 2-phenyl (and substituted phenyl) imidazo[1,2-b]pyridazines is consistent with the model of Bz receptor ligands as proposed by Fryer [Raven Press, 1983, pp. 7-20]. Several compounds were identified which had more selective activity at peripheral-type (mitochondrial) Bz binding sites. Thus, substituted imidazo[1,2-b]pyridazines represent yet another class of low molecular mass compounds which have activity at Bz receptor sites. |
| CAS Registry Number: |
|
| Synonyms: |
;1,5-Diazaindolizine;Imdazo1,2-Bpyridazine;Imidazo1,2-pyridazine;Imidazo[1,2-b]pyridazine hemi-hydrate;IPZ;Imidazo(1,2-b)pyridazine;Imidazol[1,2-b]pyridazine; |
| Molecular Formula: |
C6H5N3 |
| Molecular Weight: |
119.124 |
| Molecular Structure: |
![766-55-2 Imidazo[1,2-b]pyridazine](https://images.chemnet.com/suppliers/chembase/198/198609_1.gif)
|
| Hazard Symbols: |
 Xi:;
|
| Company: |
Jinan Chenghishaungda Chemical Co.,LTD
[ China ]
|
| Contact: |
Allen |
| Tel: |
15689693073 |
| Fax: |
0531-58897032 |
| Email: |
3118607598@qq.com |
-
Disclaimer statement:The information and data included above have been realized by the enterprises and compiled by the staff, and are subject to change without notice to you. The Chemnet makes no warranties or representations whatsoever regarding the facticity, accuracy and validity of such information and data. In order to ensure your interest, we suggest you chose the products posted by our gold suppliers or VIP members.
